FT-COMAR: fault tolerant three-dimensional structure reconstruction from protein contact maps
نویسندگان
چکیده
منابع مشابه
FT-COMAR: fault tolerant three-dimensional structure reconstruction from protein contact maps
UNLABELLED Fault Tolerant Contact Map Reconstruction (FT-COMAR) is a heuristic algorithm for the reconstruction of the protein three-dimensional structure from (possibly) incomplete (i.e. containing unknown entries) and noisy contact maps. FT-COMAR runs within minutes, allowing its application to a large-scale number of predictions. AVAILABILITY http://bioinformatics.cs.unibo.it/FT-COMAR
متن کاملFault Tolerance for Large Scale Protein 3D Reconstruction from Contact Maps
In this paper we describe FT-COMAR an algorithm that improves fault tolerance of our heuristic algorithm (COMAR) previously described for protein reconstruction [10]. The algorithm [COMAR-Contact Map Reconstruction] can reconstruct the three-dimensional (3D) structure of the real protein from its contact map with 100% efficiency when tested on 1760 proteins from different structural classes. He...
متن کاملOn the Reconstruction of Three-dimensional Protein Structures from Contact Maps
The problem of protein structure prediction is one of the long-standing goals of Computational Biology. Although we are still not able to provide first principle solutions, several shortcuts have been discovered to compute the protein three-dimensional structure when similar protein sequences are available (by means of comparative modeling and remote homology detection). Nonetheless, these appr...
متن کاملRecovery of protein structure from contact maps.
BACKGROUND Prediction of a protein's structure from its amino acid sequence is a key issue in molecular biology. While dynamics, performed in the space of two-dimensional contact maps, eases the necessary conformational search, it may also lead to maps that do not correspond to any real three-dimensional structure. To remedy this, an efficient procedure is needed to reconstruct three-dimensiona...
متن کاملReconstruction of the protein structures from contact maps
The physical protein contact map is a distinctive signature of its folded structure and contains information on all the subtle interactions within contacts among residues responsible of protein stability/function. It is a common believe that an efficient prediction of protein contact maps from the protein chains will help in finding solutions to the protein folding problem. It is therefore urge...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btn115